Referenced in: none

Automatically associated channels: Kir2.1

Title: Molecular cloning and expression of a bovine endothelial inward rectifier potassium channel.

Authors: S E Forsyth, A Hoger, J H Hoger

Journal, date & volume: FEBS Lett., 1997 Jun 9 , 409, 277-82

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9202161

Abstract
A 5.1 kb cDNA encoding an inward rectifier K+ channel (BIK) was isolated from a bovine aortic endothelial cell library. The cDNA codes for a 427-amino-acid protein with two putative transmembrane regions. Sequence analysis reveals that BIK is a member of the Kir2.1 family of inward rectifier K+ channels. Expression in Xenopus oocytes showed that BIK is a K+-specific strong inward rectifier channel that is sensitive to extracellular Ba2+, Cs+, and a variety of anti-arrhythmic agents. Northern analysis revealed that endothelial cells express a 5.5 kb BIK mRNA that is sensitive to shear stress.