Referenced in: none

Automatically associated channels: Kir2.1

Title: Molecular cloning and expression of a human heart inward rectifier potassium channel.

Authors: K F Raab-Graham, C M Radeke, C A Vandenberg

Journal, date & volume: Neuroreport, 1994 Dec 20 , 5, 2501-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/7696590

Abstract
We have isolated a cDNA encoding an inwardly rectifying K+ channel (HH-IRK1) from human heart. The cDNA codes for a 427-amino acid protein, with two putative transmembrane domains and an H5 region. The primary structure of HH-IRK1 is homologous to that of the IRK1 channel cloned from a mouse macrophage-like cell line. Functional expression in Xenopus oocytes showed that HH-IRK1 is a K+ channel with strong inward rectification, blocked by extracellular Ba2+ and Cs+, and with a single-channel conductance of 30 pS. Northern analysis showed HH-IRK1 transcripts in human heart, brain, skeletal muscle, placenta, lung and kidney. HH-IRK1 was mapped to human chromosome 17.