Referenced in: none

Automatically associated channels: Kv7.1

Title: Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion.

Authors: Nils W G Lambrecht, Iskandar Yakubov, David Scott, George Sachs

Journal, date & volume: Physiol. Genomics, 2005 Mar 21 , 21, 81-91

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15613615

Abstract
Genomic microarray analysis of genes specifically expressed in a pure cell isolate from a heterocellular organ identified the likely K efflux channel associated with the gastric H-K-ATPase. The function of this channel is to supply K to the luminal surface of the pump to allow H for K exchange. KCNQ1-KCNE2 was the most highly expressed and significantly enriched member of the large variety of K channels expressed in the gastric epithelium. The function of this K channel in acid secretion was then shown by inhibition of secretion in isolated gastric glands with specific KCNQ inhibitors and by colocalization of the channel with the H-K-ATPase in the secretory canaliculus of the parietal cell. KCNQ1-KCNE2 appears to be the K efflux channel that is essential for gastric acid secretion.