PubMed 20823649

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: KCNQ1 , Kv7.1

Title: Aborted cardiac arrest in a patient carrying KCNE1 D85N variant during the postpartum period.

Authors: Tadashi Nakajima, Yoshiaki Kaneko, Mamoru Manita, Tatsuya Iso, Masahiko Kurabayashi

Journal, date & volume: Intern. Med., 2010 , 49, 1875-8

PubMed link:

The postpartum period is associated with an increased risk of fatal ventricular tachyarrhythmias in patients with congenital long QT syndrome (LQTS). We describe a 20-year-old female with LQTS who experienced aborted cardiac arrest during the postpartum period. Genetic screening identified a KCNE1 D85N variant, which has been reported to be a LQTS-causing gene variant, in the patient and her younger sister, whose QT interval was also prolonged. Since the allele frequency of this variant is almost 1%, it may be important to clarify whether such variant carriers indeed have an increased risk of fatal ventricular tachyarrhythmias during the postpartum period.