Referenced in: none

Automatically associated channels: Kv7.1

Title: Differential expression of KCNQ1 K+ channel in tubular cells of frog kidney.

Authors: S Cirović, J Marković-Lipkovski, J Todorović, J Nesović-Ostojić, M Jović, S Ilić, S Tatić, D Cemerikic

Journal, date & volume: Eur J Histochem, 2010 Jan-Mar , 54, e7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20353914

Abstract
The aim of this study was to evaluate KCNQ1 K+ channel expression in the frog kidney of Rana esculenta. KCNQ1 K+ channel, also known as KvLQT1, is the pore forming a-subunit of the IKs K+ channel, a delayed rectifier voltage-gated K+ channel, which has an important role in water and salt transport in the kidney and gastrointestinal tract. The expression of KCNQ1 K+ channel along tubular epithelium differs from species to species. In the present study the expression of KCNQ1 K+ channel in the frog kidney has been demonstrated by immunohistochemistry. The presence of KCNQ1 K+ channel was demonstrated in the epithelial cells of distal convoluted tubule and collecting duct. However, the pattern of expression of KCNQ1 K+ channel differs between distal convoluted tubules and collecting duct. All epithelial cells of distal convoluted tubules revealed basolateral expression of KCNQ1 K+ channel. On the contrary, only the single cells of collecting duct, probably intercalated cells, showed diffuse cell surface staining with antibodies against KCNQ1 K+ channel. These findings suggest that KCNQ1 K+ channel has cell-specific roles in renal potassium ion transport.