Referenced in: none

Automatically associated channels: Kv7.1

Title: No potassium, no acid: K+ channels and gastric acid secretion.

Authors: Dirk Heitzmann, Richard Warth

Journal, date & volume: , 2007 Oct , 22, 335-41

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17928547

Abstract
The gastric H+-K+-ATPase pumps H+ into the lumen and takes up K+ in parallel. In the acid-producing parietal cells, luminal KCNE2/KCNQ1 K+ channels play a pivotal role in replenishing K+ in the luminal fluid. Inactivation of KCNE2/KCNQ1 channels abrogates gastric acid secretion and dramatically modifies the architecture of gastric mucosa.