Channelpedia

PubMed 26250931


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: KCNQ1 , Kv7.1



Title: [Long QT syndrome : History, genetics, clinical symptoms, causes and therapy].

Authors: T Krönauer, P Friederich

Journal, date & volume: Anaesthesist, 2015 Aug , 64, 586-95

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/26250931


Abstract
The long QT syndrome is caused by a change in cardiac repolarization due to functional ion channel defects. A differentiation is made between a congenital (cLQTS) and an acquired (aLQTS) form of the disease. The disease results in the name-giving prolongation of the QT interval in the electrocardiogram and represents a predisposition for cardiac arrhythmia and sudden cardiac death. This article summarizes the current knowledge on the history, pathophysiology, clinical symptoms and therapy of cLQTS and aLQTS. This knowledge of pathophysiological features of the symptoms allows the underlying anesthesiological approach for individualized perioperative concepts for patients suffering from LQTS to be derived.