Channelpedia

PubMed 22421958


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: KCNQ1 , Kv7.1 , Slo1



Title: Stoichiometry of the slow I(ks) potassium channel in human embryonic stem cell-derived myocytes.

Authors: Mi Wang, Robert S Kass

Journal, date & volume: Pediatr Cardiol, 2012 Aug , 33, 938-42

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22421958


Abstract
The delayed rectifier I(ks) potassium channel is composed of α-(KCNQ1) and β-(KCNE1) subunits. The stoichiometry of I(ks) channels is a matter of some debate. Recently some investigators proposed that the number of KCNE1 subunits per KCNQ1 tetramer could be vary from one to four depending on the relative expression of these two genes. Here we review our previous study of biophysical properties of I(ks) in human embryonic stem cell-derived cardiomyocytes (hESC-CMs) showed that I(ks) in hESC-CMs is a coassembly channel with a stoichiometry other than 1:1, which could be further modulated by additional KCNE1.