Referenced in: none

Automatically associated channels: Kv11.1 , Kv7.1 , Slo1

Title: Modelling and imaging cardiac repolarization abnormalities.

Authors: Y Rudy

Journal, date & volume: J. Intern. Med., 2006 Jan , 259, 91-106

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/16336517

Abstract
Repolarization abnormalities, including those induced by the congenital or acquired long QT (LQT) syndrome, provide a substrate for life-threatening cardiac arrhythmias. In this article, we use computational biology to link HERG mutations mechanistically to the resulting abnormalities of the whole-cell action potential. We study how the kinetic properties of I(Ks) (the slow delayed rectifier) that are conferred by molecular subunit interactions, facilitate its role in repolarization and 'repolarization reserve'. A new noninvasive imaging modality (electrocardiographic imaging) is shown to image cardiac repolarization on the epicardial surface, suggesting its possible role in risk stratification, diagnosis and treatment of LQT syndrome.