Referenced in: none

Automatically associated channels: K2P , Kir1.1 , Kir4.1 , Kv7.1 , TASK2

Title: KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.

Authors: Yves Cazals, Michelle Bévengut, Sebastien Zanella, Frédéric Brocard, Jacques Barhanin, Christian Gestreau

Journal, date & volume: Nat Commun, 2015 , 6, 8780

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/26549439

Abstract
In the cochlea, K(+) is essential for mechano-electrical transduction. Here, we explore cochlear structure and function in mice lacking K(+) channels of the two-pore domain family. A profound deafness associated with a decrease in endocochlear potential is found in adult Kcnk5(-/-) mice. Hearing occurs around postnatal day 19 (P19), and completely disappears 2 days later. At P19, Kcnk5(-/-) mice have a normal endolymphatic [K(+)] but a partly lowered endocochlear potential. Using Lac-Z as a gene reporter, KCNK5 is mainly found in outer sulcus Claudius', Boettcher's and root cells. Low levels of expression are also seen in the spiral ganglion, Reissner's membrane and stria vascularis. Essential channels (KCNJ10 and KCNQ1) contributing to K(+) secretion in stria vascularis have normal expression in Kcnk5(-/-) mice. Thus, KCNK5 channels are indispensable for the maintenance of hearing. Among several plausible mechanisms, we emphasize their role in K(+) recycling along the outer sulcus lateral route.