Referenced in: none

Automatically associated channels: Kv7.1

Title: KCNQ1 loss-of-function mutation impairs gastric acid secretion in mice.

Authors: Qin Pan, Jun Ma, Qinshu Zhou, Jun Li, Yongqing Tang, Yi Liu, Yiqing Yang, Junjie Xiao, Luying Peng, Pengjuan Li, Dandan Liang, Hong Zhang, Yi-Han Chen

Journal, date & volume: Mol. Biol. Rep., 2010 Mar , 37, 1329-33

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19306073

Abstract
The KCNQ1 channel is abundantly expressed in the gastric parietal cells. Although the functional coupling of KCNQ1 with the H(+)/K(+)-ATPase has already been confirmed on the basis of pharmacological kinetics, the effect of a KCNQ1 loss-of-function mutation on gastric acidification remains unclear. In this study, parietal cells and gastric glands from both C57BL/6 J mice (normal control) and J343 mice (mice with a KCNQ1 loss-of-function mutation) were isolated to study the effects of KCNQ1 on gastric acidification. We found that the mutation limited intracellular acidification of parietal cells and H(+) secretion of the stomach in response to histamine. Thus, a KCNQ1 loss-of-function mutation may impair gastric acid secretion.