Channelpedia

PubMed 22923468


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Automatically associated channels: KCNQ1 , Kir1.1 , Kir6.2 , Kv7.1



Title: Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.

Authors: Marco Alberto Gamboa-Meléndez, Alicia Huerta-Chagoya, Hortensia Moreno-Macías, Paola Vázquez-Cárdenas, María Luisa Ordóñez-Sánchez, Rosario Rodríguez-Guillén, Laura Riba, Maribel Rodríguez-Torres, María Teresa Guerra-García, Luz Elizabeth Guillén-Pineda, Shweta Choudhry, Laura Del Bosque-Plata, Samuel Canizales-Quinteros, Gustavo Pérez-Ortiz, Fernando Escobedo-Aguirre, Adalberto Parra, Israel Lerman-Garber, Carlos Alberto Aguilar-Salinas, Maria Teresa Tusié-Luna

Journal, date & volume: Diabetes, 2012 Dec , 61, 3314-21

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22923468


Abstract
Several studies have identified nearly 40 different type 2 diabetes susceptibility loci, mainly in European populations, but few of them have been evaluated in the Mexican population. The aim of this study was to examine the extent to which 24 common genetic variants previously associated with type 2 diabetes are associated in Mexican Mestizos. Twenty-four single nucleotide polymorphisms (SNPs) in or near genes (KCNJ11, PPARG, TCF7L2, SLC30A8, HHEX, CDKN2A/2B, CDKAL1, IGF2BP2, ARHGEF11, JAZF1, CDC123/CAMK1D, FTO, TSPAN8/LGR5, KCNQ1, THADA, ADAMTS9, NOTCH2, NXPH1, RORA, UBQLNL, and RALGPS2) were genotyped in Mexican Mestizos. A case-control association study comprising 1,027 type 2 diabetic individuals and 990 control individuals was conducted. To account for population stratification, a panel of 104 ancestry-informative markers was analyzed. Association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1). In addition, rs7754840 (CDKAL1) was associated in the nonobese type 2 diabetic subgroup, and for rs7903146 (TCF7L2), association was observed for early-onset type 2 diabetes. Lack of association for the rest of the variants may have resulted from insufficient power to detect smaller allele effects.