Referenced in: none

Automatically associated channels: Kv7.1

Title: KCNQ1 gene variants and risk of new-onset diabetes in tacrolimus-treated renal-transplanted patients.

Authors: Beatriz Tavira, Eliecer Coto, Carmen Díaz-Corte, Francisco Ortega, Manuel Arias, Armando Torres, Juan M Díaz, Rafael Selgas, Carlos López-Larrea, Jose M Campistol, Marta Ruiz-Ortega, Victoria Alvarez,

Journal, date & volume: Clin Transplant, 2011 May , 25, E284-91

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21355884

Abstract
Recent genome-wide association studies identified single-nucleotide polymorphisms (SNPs) in the gene encoding the pore-forming subunit of the voltage-gated K+ channel (KCNQ1) as a risk factor for type 2 diabetes. Tacrolimus (Tac) increased the risk of new-onset diabetes after transplantation (NODAT). The aim of this study was to analyze the association between KCNQ1 variants and the risk for NODAT in kidney-transplanted patients who received Tac as primary immunosuppressor. We genotyped three common KCNQ1 SNPs in 145 Spanish patients who received a cadaveric kidney graft and developed NODAT in the first-year post-transplant (the NODAT group), and 260 patients who remained non-diabetics (non-NODAT). In addition, we searched for DNA variants in the whole KCNQ1 coding exons in these patients. SNP rs2237895 (genotype CC) was associated with an increased risk for NODAT in our population (p = 0.008; OR = 1.83, 95% CI = 1.14-2.93), independently of other risk factors as body mass index, recipient age, or tacrolimus dosage. Other KCNQ1 variants were not associated with NODAT in our patients. Our work supported a role for KCNQ1 gene variants as determinants of the risk of developing NODAT among Tac-treated patients.