Channelpedia

PubMed 24724419


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: KCNQ1 , Kv7.1



Title: [Current status and future perspective in inherited cardiac arrhythmias].

Authors: Wataru Shimizu

Journal, date & volume: Nippon Rinsho, 2014 Mar , 72, 553-63

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24724419


Abstract
Some patients with inherited cardiac arrhythmias such as congenital long QT syndrome (LQTS), Brugada syndrome, and early repolarization syndrome (ERS) have a link to mutations in genes encoding for ion channels or other membrane components. The diagnosis and management for inherited cardiac arrhythmias have been updated in recently published HRS/EHRA/APHRS Expert Consensus Statement. More recently, an exome study or whole genome study by using next generation sequencer as well as a genome-wide association study (GWAS) by using a gene array have been introduced to identify a new responsible gene or to explore the role of common genetic variants (polymorphisms) as a susceptible or modifier gene in inherited cardiac arrhythmias.