Referenced in: none

Automatically associated channels: Kv7.1 , Slo1

Title: Binding properties of sea anemone toxins to sodium channels in the crayfish giant axon.

Authors: A Warashina, T Ogura, S Fujita

Journal, date & volume: Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol., 1988 , 90, 351-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2902997

Abstract
1. Effects of four different sea anemone toxins from Anthopleura (AP-A and AP-C), Anemonia (ATX II) and Parasicyonis (PaTX), and a scorpion toxin from Leiurus (LqTX) on crayfish giant axons were studied. 2. These toxins slowed the Na channel inactivation process, inducing a maintained Na current during a depolarizing pulse. 3. The binding rates for these toxins markedly decreased under depolarization. The decrease in AP-A binding was mainly derived from an increased dissociation rate under depolarization whereas that in PaTX binding from a reduced association rate. 4. The potential-dependent toxin binding kinetics seemed to be related to the gating mechanism of the Na channel. 5. Competitive bindings between these toxins were demonstrated.