Channelpedia

PubMed 27261821


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: KCNQ1 , Kv1.5 , Kv11.1 , Kv7.1 , Slo1



Title: Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology.

Authors: Wei Wu, Michael C Sanguinetti

Journal, date & volume: Card Electrophysiol Clin, 2016 Jun , 8, 275-84

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/27261821


Abstract
Human cardiomyocytes express 3 distinct types of delayed rectifier potassium channels. Human ether-a-go-go-related gene (hERG) channels conduct the rapidly activating current IKr; KCNQ1/KCNE1 channels conduct the slowly activating current IKs; and Kv1.5 channels conduct an ultrarapid activating current IKur. Here the authors provide a general overview of the mechanistic and structural basis of ion selectivity, gating, and pharmacology of the 3 types of cardiac delayed rectifier potassium ion channels. Most blockers bind to S6 residues that line the central cavity of the channel, whereas activators interact with the channel at 4 symmetric binding sites outside the cavity.