Referenced in: none

Automatically associated channels: Kv7.1

Title: A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.

Authors: Fuu-Jen Tsai, Chi-Fan Yang, Ching-Chu Chen, Lee-Ming Chuang, Chieh-Hsiang Lu, Chwen-Tzuei Chang, Tzu-Yuan Wang, Rong-Hsing Chen, Chiung-Fang Shiu, Yi-Min Liu, Chih-Chun Chang, Pei Chen, Chien-Hsiun Chen, Cathy S J Fann, Yuan-Tsong Chen, Jer-Yuarn Wu

Journal, date & volume: PLoS Genet., 2010 , 6, e1000847

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20174558

Abstract
To investigate the underlying mechanisms of T2D pathogenesis, we looked for diabetes susceptibility genes that increase the risk of type 2 diabetes (T2D) in a Han Chinese population. A two-stage genome-wide association (GWA) study was conducted, in which 995 patients and 894 controls were genotyped using the Illumina HumanHap550-Duo BeadChip for the first genome scan stage. This was further replicated in 1,803 patients and 1,473 controls in stage 2. We found two loci not previously associated with diabetes susceptibility in and around the genes protein tyrosine phosphatase receptor type D (PTPRD) (P = 8.54x10(-10); odds ratio [OR] = 1.57; 95% confidence interval [CI] = 1.36-1.82), and serine racemase (SRR) (P = 3.06x10(-9); OR = 1.28; 95% CI = 1.18-1.39). We also confirmed that variants in KCNQ1 were associated with T2D risk, with the strongest signal at rs2237895 (P = 9.65x10(-10); OR = 1.29, 95% CI = 1.19-1.40). By identifying two novel genetic susceptibility loci in a Han Chinese population and confirming the involvement of KCNQ1, which was previously reported to be associated with T2D in Japanese and European descent populations, our results may lead to a better understanding of differences in the molecular pathogenesis of T2D among various populations.