Channelpedia

PubMed 18827480


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: KCNQ1 , KCNQ2 , KCNQ3 , KCNQ4 , Kv7.1 , Kv7.2 , Kv7.3 , Kv7.4 , Slo1



Title: Expression and localization of K channels KCNQ2 and KCNQ3 in the mammalian cochlea.

Authors: Zhe Jin, Gui-Hua Liang, Edward C Cooper, Leif Jarlebark

Journal, date & volume: Audiol. Neurootol., 2009 , 14, 98-105

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18827480


Abstract
KCNQ1 and KCNQ4 voltage-gated potassium channel subunits play key roles in hearing. Other members of the KCNQ family also encode slow, low voltage-activated K(+) M currents. We have previously reported the presence of M-like K(+) currents in sensory hair cells, and expression of Kcnq family genes in the cochlea. Here, we describe Kcnq2/3 gene expression and distribution of M channel subunits KCNQ2 and 3 in the cochlea. By using RT-PCR, we found expression of Kcnq2 in the modiolus and organ of Corti, while Kcnq3 expression was also detected in the cochlear lateral wall. Five alternative splice variants of the Kcnq2 gene, one of which has not been reported previously, were identified in the rat cochlea. KCNQ2 and KCNQ3 immunoreactivities were observed in spiral ganglion auditory neurons. In addition, the unmyelinated parts of the nerve fibers innervating hair cells and synaptic regions under hair cells showed KCNQ2 immunoreactivity. KCNQ3 immunoreactivity was also prominent in spiral ganglion satellite cells. These findings suggest that cochlear M channels play important roles in regulation of cellular excitability and maintenance of cochlear K(+) homeostasis in the auditory system.