Referenced in: none

Automatically associated channels: Kv11.1 , Kv7.1

Title: T-wave patterns associated with the hereditary long QT syndrome.

Authors: Arthur J Moss

Journal, date & volume: , 2002 Sep , 6, 311-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/12114857

Abstract
Mutations involving 6 different ion-channel genes have been identified in subjects with the hereditary Long QT Syndrome. These gene mutations result in structural and functional changes in ion-channel proteins with resultant alterations in potassium and sodium repolarization currents that affect the morphologic features of electrocardiographic repolarization. This review highlights the genotype-phenotype associations related to ventricular repolarization that have been reported in the LQTS literature, with particular focus on ECG T-wave patterns in LQT1, LQT2, and LQT3 genotypes.