PubMed 22354620

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: KCNQ1 , Kv7.1

Title: A left ventricular noncompaction in a patient with long QT syndrome caused by a KCNQ1 mutation: a case report.

Authors: Kentaro Nakashima, Isao Kusakawa, Tsuyoshi Yamamoto, Shinsuke Hirabayashi, Ryohta Hosoya, Wataru Shimizu, Naokata Sumitomo

Journal, date & volume: Heart Vessels, 2013 Jan , 28, 126-9

PubMed link:

A 5-year-old girl developed cardiopulmonary arrest after crying. From the electrocardiogram and echocardiography, a left ventricular noncompaction (LVNC) with long QT syndrome (LQT) was suspected as the cause of the cardiopulmonary arrest, and treatment with a β-blocker and a calcium antagonist was then begun. A genetic screening of LQT-related genes revealed a previously reported heterozygous KCNQ1 mutation. The association of LVNC and LQT is an extremely rare condition, and long-term treatment based on the characteristics of both disorders is required. Also, the association of cardiomyopathy and LQT could become a new clinical entity in the future.