Referenced in: none

Automatically associated channels: Kv7.1

Title: Phenotypic analysis of vertigo 2 Jackson mice with a Kcnq1 potassium channel mutation.

Authors: Takeshi Takagi, Hajime Nishio, Takeo Yagi, Masayoshi Kuwahara, Hirokazu Tsubone, Nobuhiko Tanigawa, Koichi Suzuki

Journal, date & volume: Exp. Anim., 2007 Jul , 56, 295-300

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17660684

Abstract
The KCNQ1 gene encodes a voltage-dependent potassium ion channel, and mutations in this gene are the most common cause of congenital long QT syndrome (LQTS). In the present study, we investigated the various phenotypic characteristics of vertigo 2 Jackson (C3H/HeJCrl-Kcnq1(vtg-2J)/J) mice with a Kcnq1 mutation. Both heterozygotes (vtg-2J/+) and homozygotes (vtg-2J/vtg-2J) showed prolonged QT intervals in electrocardiograms (ECGs) compared to C3H/HeJ control (+/+) mice. Furthermore, vtg-2J/vtg-2J mice showed gastric achlorhydria associated with elevation of their serum gastrin levels. The serum corticosterone levels were also significantly increased in vtg-2J/vtg-2J mice. In addition, vtg-2J/vtg-2J mice exhibited significantly higher blood pressure. These findings indicate that the Kcnq1 mutation in vtg-2J mice alters various physiological functions in the cardiac, gastric and adrenocortical systems, and suggest that vtg-2J mice may represent a useful model for studying Kcnq1 functions.