Referenced in: none

Automatically associated channels: ClC2 , ClC4

Title: Chloride channels ClC-2 and ICln mRNA expression differs in renal epithelial ontogeny.

Authors: S Huber, G Braun, B Schröppel, M Horster

Journal, date & volume: Kidney Int. Suppl., 1998 Sep , 67, S149-51

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9736273

Abstract
Development-dependent mRNA expression of the chloride channels ClC-2 and ICln was studied by quantitative reverse transcriptase-polymerase chain reaction in rat ureteric bud and cortical collecting duct primary monolayer cultures. Abundance of ClC-2 mRNA increased in ureteric bud cells between embryonic day 15 (E15) and E17, peaked at postnatal day 3 (P3), and was down-regulated at P7 when morphogenesis is complete, suggesting a specific embryonic function. Expression of ICln mRNA, in contrast, up-regulated continuously with development.