Referenced in: none

Automatically associated channels: ClC2 , ClC4

Title: Mutations in the CLCN2 gene are a rare cause of idiopathic generalized epilepsy syndromes.

Authors: E Stogmann, P Lichtner, C Baumgartner, M Schmied, C Hotzy, F Asmus, F Leutmezer, S Bonelli, E Assem-Hilger, K Vass, K Hatala, T M Strom, T Meitinger, F Zimprich, A Zimprich

Journal, date & volume: Neurogenetics, 2006 Nov , 7, 265-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/16932951

Abstract
Mutations in the chloride channel gene CLCN2 have been reported in families with generalized and focal epilepsy syndromes. To evaluate the contribution of mutations in the CLCN2 gene to the etiology of epilepsies in our population, we screened 96 patients with different epilepsy syndromes and a putative genetic background. No definite mutations were found in our study population. We conclude that mutations in the CLCN2 gene are only a rare cause of idiopathic generalized epilepsy.