Referenced in: none

Automatically associated channels: ClC2 , ClC4

Title: Cereblon is expressed in the retina and binds to voltage-gated chloride channels.

Authors: Bettina Hohberger, Ralf Enz

Journal, date & volume: FEBS Lett., 2009 Feb 18 , 583, 633-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19166841

Abstract
The function of the central nervous system depends on the correct regulation of ion channels by interacting proteins. Here, we identified cereblon as a new interactor of the voltage-gated chloride channel ClC-2. A distal region of the ClC-2 C-terminus interacts with the Lon domain of cereblon. Cereblon is expressed in several brain regions including the retina. There, we detected cereblon in nuclear and synaptic layers and localized the protein in the same subcellular region of bipolar cell bodies previously reported to express ClC-2. Our data suggest that cereblon might be associated with voltage-gated chloride channels in the central nervous system.