Referenced in: none

Automatically associated channels: ClC2 , ClC4

Title: Of mice and worms: novel insights into ClC-2 anion channel physiology.

Authors: Kevin Strange

Journal, date & volume: News Physiol. Sci., 2002 Feb , 17, 11-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/11821530

Abstract
ClC anion channels are found in all major groups of organisms. Recent studies in nematodes and mice suggest that the function and regulation of ClC-2 have been conserved over vast evolutionary time spans. These studies illustrate the experimental advantages of using genomically defined nonmammalian model organisms for characterizing ClC channel functional genomics.