Referenced in: none

Automatically associated channels: ClC2 , ClC4

Title: Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2.

Authors: Csaba Földy, Sang-Hun Lee, Robert J Morgan, Ivan Soltesz

Journal, date & volume: Nat. Neurosci., 2010 Sep , 13, 1047-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20676104

Abstract
Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.