Referenced in: none

Automatically associated channels: ClC1 , ClC2 , ClC4

Title: Heteromultimeric CLC chloride channels with novel properties.

Authors: C Lorenz, M Pusch, T J Jentsch

Journal, date & volume: Proc. Natl. Acad. Sci. U.S.A., 1996 Nov 12 , 93, 13362-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8917596

Abstract
The skeletal muscle chloride channel CLC-1 and the ubiquitous volume-activated chloride channel CLC-2 belong to a large gene family whose members often show overlapping expression patterns. CLC-1 and CLC-2 are coexpressed in skeletal and smooth muscle and in the heart. By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride-->bromide-->iodide selectivity sequence. Formation of heterooligomeric CLC channels increases the number and possible functions of chloride channels.