Referenced in: none

Automatically associated channels: ClC1 , ClC2 , ClC4

Title: Disruption of clh-1, a chloride channel gene, results in a wider body of Caenorhabditis elegans.

Authors: M I Petalcorin, T Oka, M Koga, K Ogura, Y Wada, Y Ohshima, M Futai

Journal, date & volume: J. Mol. Biol., 1999 Nov 26 , 294, 347-55

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10610763

Abstract
We cloned the clh-1 gene coding for a putative ClC chloride channel in Caenorhabditis elegans. The gene product exhibited a high degree of homology with human ClC-1 and ClC-2. The clh-1 gene was predominantly expressed in the hypodermis, including seam cells. Null mutations of clh-1 caused a significantly wider body and an abnormal alae structure. High osmolarity in the culture medium restored the normal body width of the clh-1 mutants. These results suggest that the clh-1 gene contributes to maintenance of the body width through regulation of osmolarity.