PubMed 18812204

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Title: SCN8A as a novel candidate gene associated with bipolar disorder in the Han Chinese population.

Authors: Yang Wang, Jing Zhang, Xingwang Li, Jue Ji, Fengping Yang, Chunling Wan, Guoyin Feng, Peng Wan, Lin He, Guang He

Journal, date & volume: Prog. Neuropsychopharmacol. Biol. Psychiatry, 2008 Dec 12 , 32, 1902-4

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Bipolar disorder (BPD) is a common, severe and recurrent psychiatric disorder. It has been suggested that BPD patients have a higher risk of suicide than patients with any other psychiatric illnesses. A recent study found that suicide attempt was associated with the SCN8A gene, which has been mapped close to one of the BPD susceptibility loci. Thus, SCN8A is likely to be a candidate gene for BPD.In this study, three SNPs (rs1601012, rs303810, rs60637) were analyzed in 506 bipolar patients and 507 controls of Han origin.We found that two individual SNPs showed statistically significant differences between cases and controls in both allele and genotype distribution, but only rs303810 was still significant in allele distribution (p=0.0164) after correction. No obvious linkage disequilibrium or haplotypes were observed among these SNPs.Our results indicate that SCN8A may be a potential susceptibility gene for bipolar disorder in the Han Chinese population.