Referenced in: none

Automatically associated channels: Nav1.6

Title: Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons.

Authors: Theodore R Cummins, Sulayman D Dib-Hajj, Raimund I Herzog, Stephen G Waxman

Journal, date & volume: FEBS Lett., 2005 Apr 11 , 579, 2166-70

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15811336

Abstract
The Na(v)1.6 voltage-gated sodium channel has been implicated in the generation of resurgent currents in cerebellar Purkinje neurons. Our data show that resurgent sodium currents are produced by some large diameter dorsal root ganglion (DRG) neurons from wild-type mice, but not from Na(v)1.6-null mice; small DRG neurons do not produce resurgent currents. Many, but not all, DRG neurons transfected with Na(v)1.6 produce resurgent currents. These results demonstrate for the first time the intrinsic ability of Na(v)1.6 to produce a resurgent current, and also show that cell background is critical in permitting the generation of these currents.