PubMed 20974533

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.3

Title: Substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 ion channel blockers. Part 2.

Authors: Curt D Haffner, Stephen A Thomson, Yu Guo, Kimberly Petrov, Andrew Larkin, Pierette Banker, Gregory Schaaf, Scott Dickerson, Jeff Gobel, Dan Gillie, J Patrick Condreay, Chuck Poole, Tiffany Carpenter, John Ulrich

Journal, date & volume: , 2010 Oct 23 , ,

PubMed link:

We report the synthesis and in vitro activity of a series of novel substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs. These analogs showed potent inhibitory activity against Kv1.3. Several demonstrated similar potency to the known Kv1.3 inhibitor PAP-1 when tested under the IonWorks patch clamp assay conditions. Two compounds 13i and 13rr were advanced further as potential tool compounds for in vivo validation studies.