Channelpedia

PubMed 19149654


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.3 , Slo1



Title: A quantitative structure-activity relationship study on some series of potassium channel blockers.

Authors: V S A Kumar Satuluri, Jyostna Seelam, S P Gupta

Journal, date & volume: , 2009 Jan , 5, 87-92

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19149654


Abstract
There has been an increasing interest in compounds that modulate potassium ion channels (K(+)-channels) since they can be developed as important therapeutic agents against ischemic heart diseases. Of the diverse family of K(+)-channels, the voltage-gated potassium channel Kv1.3 constitutes an attractive target for the selective suppression of effector memory T cells in autoimmune diseases. For the development of antiarrythmic drugs, the blockade of the rapidly activating delayed rectifier (I(Kr)) and slowly activating delayed rectifier (I(Ks)) potassium currents has been specifically studied. Since the discovery of I(Ks)-channel, its blockers have been particularly more studied. In this communication, we present QSAR studies on a few series of Kv1.3-channel blockers and a series of I(Ks)-channel blockers in order to provide some guidelines to the drug development.