Referenced in: none

Automatically associated channels: Kv1.3

Title: Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3.

Authors: Julia Cianci, Jonathan B Baell, Bernard L Flynn, Robert W Gable, Jorgen A Mould, Dharam Paul, Andrew J Harvey

Journal, date & volume: Bioorg. Med. Chem. Lett., 2008 Mar 15 , 18, 2055-61

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18289849

Abstract
Chalcone derivatives of the natural product khellinone were synthesised and screened for bioactivity against the voltage-gated potassium channel Kv1.3. X-ray crystallography was employed to investigate relationships between the structure and function of a selection of the reported chalcones.