Referenced in: none

Automatically associated channels: Kv1.3

Title: 3-Alkyl- and 3-aryl-7H-furo[3,2-g]chromen-7-ones as blockers of the voltage-gated potassium channel Kv1.3.

Authors: A Wernekenschnieder, P Körner, W Hänsel

Journal, date & volume: Pharmazie, 2004 Apr , 59, 319-20

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15125582

Abstract
3-Alkyl- and 3-aryl-7H-furo[3,2-g]chromen-7-ones were synthesised and studied for their effects on voltage-gated K+ and Na+ channels of the neuroblastoma cell-line N1E-115 and K+ channels of L-929 mouse-fibroblasts, stably transfected with mKv1.3. All furocoumarins tested showed Kv channel blocking activities, the most potent one in a half-blocking concentration of 0.7 microM.