PubMed 20971642

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.3

Title: N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 inhibitors. Part 1.

Authors: Curt D Haffner, Stephen A Thomson, Yu Guo, Lee T Schaller, Sharon Boggs, Scott Dickerson, Jeff Gobel, Dan Gillie, J Patrick Condreay

Journal, date & volume: Bioorg. Med. Chem. Lett., 2010 Dec 1 , 20, 6983-8

PubMed link:

We report the synthesis and in vitro activity of a series of novel N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs. These analogs showed potent inhibitory activity against Kv1.3. Several compounds, including compound 8b, showed similar potency to the known Kv1.3 inhibitor PAP-1 when tested under the IonWorks patch clamp assay conditions.