Channelpedia

PubMed 19282171


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.3



Title: Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants.

Authors: Stefano Pegoraro, Martin Lang, Tobias Dreker, Jürgen Kraus, Svetlana Hamm, Cathal Meere, Juliane Feurle, Stefan Tasler, Sylvia Prütting, Zerrin Kuras, Violeta Visan, Stephan Grissmer

Journal, date & volume: Bioorg. Med. Chem. Lett., 2009 Apr 15 , 19, 2299-304

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19282171


Abstract
New structural classes of K(V)1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model.