PubMed 19282171

Referenced in: none

Automatically associated channels: Kv1.3

Title: Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants.

Authors: Stefano Pegoraro, Martin Lang, Tobias Dreker, Jürgen Kraus, Svetlana Hamm, Cathal Meere, Juliane Feurle, Stefan Tasler, Sylvia Prütting, Zerrin Kuras, Violeta Visan, Stephan Grissmer

Journal, date & volume: Bioorg. Med. Chem. Lett., 2009 Apr 15 , 19, 2299-304

PubMed link:

New structural classes of K(V)1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model.