Channelpedia

PubMed 12915045


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.3



Title: K+ channels and T-cell synapses: the molecular background for efficient immunomodulation is shaping up.

Authors: János Matkó

Journal, date & volume: Trends Pharmacol. Sci., 2003 Aug , 24, 385-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/12915045


Abstract
Diverse K(+) channels exhibit differential expression and function in human lymphocytes. Voltage-gated and Ca(2+)-activated K(+) channels have a significant impact on both T-cell activation and the overall immune response. A recent study on the plasma membrane organization of Kv1.3 K(+) channels in human T cells provides new insights into the immunoregulatory functions of K(+) channels, which might result in new and improved immune suppression protocols targeted to ion channels and/or T-cell signaling and accessory molecules.