Channelpedia

PubMed 10612582


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.3



Title: Blockers of human T cell Kv1.3 potassium channels using de novo ligand design and solid-phase parallel combinatorial chemistry.

Authors: A Lew, A R Chamberlin

Journal, date & volume: Bioorg. Med. Chem. Lett., 1999 Dec 6 , 9, 3267-72

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10612582


Abstract
Blockers of the human Kv1.3 potassium channel were designed using Biosym/MSI's ligand design program LUDI. Parallel combinatorial synthesis of the resultant substituted phenyl-stilbenes on solid phase, followed by 125I Charybdotoxin (125I ChTx) screening, yielded 12 Kv1.3 channel blockers with modest activity.