Referenced in: none

Automatically associated channels: Kv1.1 , Kv1.2 , Kv1.3

Title: A new Kaliotoxin selective towards Kv1.3 and Kv1.2 but not Kv1.1 channels expressed in oocytes.

Authors: Najwa Abbas, Maya Belghazi, Yousra Abdel-Mottaleb, Jan Tytgat, Pierre E Bougis, Marie-France Martin-Eauclaire

Journal, date & volume: Biochem. Biophys. Res. Commun., 2008 Nov 21 , 376, 525-30

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18804453

Abstract
In this paper were described the purification, the sequencing, and the immunological and biological characterization of a new Kaliotoxin analog, Aam-KTX, from the venom of the scorpion Androctonus amoreuxi. The toxin effects on three cloned Kv channels (Kv1.1, Kv1.2, and Kv1.3) were investigated in Xenopus oocytes using electrophysiology experiments. The Aam-KTX preference for Kv1.3 channel versus Kv1.2 was expected (EC(50) values, 1.1+/-0.02 and 10.4+/-1.5 nM, respectively) but its total inefficacy on Kv1.1 was very surprising. 3D molecular modeling of Aam-KTX brought putative answers to this difference in selectivity.