Channelpedia

PubMed 27033404


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.3 , Nav1 , Nav1.7



Title: Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level.

Authors: Jianwei Xu, Wei Zhao, Lanying Pan, Ailian Zhang, Qingmao Chen, Kai Xu, Haiyin Lu, Yuan Chen

Journal, date & volume: Fitoterapia, 2016 Jun , 111, 1-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/27033404


Abstract
Fritillaria is one of the most important herbs in Chinese traditional medicine and represents an annual ¥700 million industry. It is often used as an anti-inflammatory, pain relieving and antitussive medicine. However, the mechanisms of these effects are still unclear. Peimine is one of active ingredients of Fritillaria. Using the patch-clamp technique, we profiled the action of Peimine against selected ion channels stably expressed in HEK 293 cell lines. Our data indicated that Peimine was not only able to block the Nav1.7 ion channel but also preferably inhibited the Kv1.3 ion channel. Thus, the study suggested potential mechanisms of Fritillaria as a pain relieving and anti-inflammatory herb.