Referenced in: none

Automatically associated channels: Kv1.3

Title: Blockade action of ketanserin and increasing effect of potassium ion on Kv1.3 channels expressed in Xenopus oocytes.

Authors: Xianpei Wang, Yuhua Liao, Anruo Zou, Lu Li, Danna Tu

Journal, date & volume: Pharmacol. Res., 2007 Aug , 56, 148-54

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17582781

Abstract
The goal of this study was to investigate the pharmacological effects of ketanserin (KT) and elevated extracellular potassium ([K+]o) on Kv1.3 potassium channels. Kv1.3 channels were expressed in Xenopus oocytes, and the resulting currents were measured using a two-microelectrode voltage-clamp technique. KT blocked Kv1.3 currents in a concentration-dependent, time-dependent and voltage-independent manner, and accelerated their activation and inactivation. Kv1.3 currents were increased by high [K+]o in a concentration-dependent manner. Our results suggest that KT acts directly on the open state of the Kv1.3 channel, whereas augmentation of extracellular [K] enhances current flow through the channel by increasing the channel's conductance.