Referenced in: none

Automatically associated channels: Kv1.3

Title: Voltage-dependent ion channels in the mouse RPE: comparison with Norrie disease mice.

Authors: Guido Wollmann, Steffen Lenzner, Wolfgang Berger, Rita Rosenthal, Mike O Karl, Olaf Strauss

Journal, date & volume: Vision Res., 2006 Mar , 46, 688-98

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/16289664

Abstract
We studied electrophysiological properties of cultured retinal pigment epithelial (RPE) cells from mouse and a mouse model for Norrie disease. Wild-type RPE cells revealed the expression of ion channels known from other species: delayed-rectifier K(+) channels composed of Kv1.3 subunits, inward rectifier K(+) channels, Ca(V)1.3 L-type Ca(2+) channels and outwardly rectifying Cl(-) channels. Expression pattern and the ion channel characteristics current density, blocker sensitivity, kinetics and voltage-dependence were compared in cells from wild-type and Norrie mice. Although no significant differences were observed, our study provides a base for future studies on ion channel function and dysfunction in transgenic mouse models.