Channelpedia

PubMed 17118788


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.3



Title: Two-dimensional solid-state NMR applied to a chimeric potassium channel.

Authors: Adam Lange, Karin Giller, Olaf Pongs, Stefan Becker, Marc Baldus

Journal, date & volume: J. Recept. Signal Transduct. Res., 2006 , 26, 379-93

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17118788


Abstract
Solid-state NMR (ssNMR) represents a spectroscopic method to study membrane protein structure and dynamics in lipid bilayers. We present two-dimensional correlation experiments conducted on a fully [13C,15N] labeled version of a chimeric potassium (KcsA-Kv1.3) channel. Data obtained by using two different ion concentrations suggest a structural conservation of the selectivity filter region. SsNMR experiments conducted at two different temperatures point to differential molecular dynamics of the channel.