Channelpedia

PubMed 11430046


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.3



Title: Candelalides A-C: novel diterpenoid pyrones from fermentations of Sesquicillium candelabrum as blockers of the voltage-gated potassium channel Kv1.3.

Authors: S B Singh, D L Zink, A W Dombrowski, G Dezeny, G F Bills, J P Felix, R S Slaughter, M A Goetz

Journal, date & volume: Org. Lett., 2001 Jan 25 , 3, 247-50

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/11430046


Abstract
[figure: see text] Blockers of the voltage-gated potassium channel Kv1.3 are potential immunosuppressants. Candelalides A-C are three novel diterpenoid pyrones that block this channel. The structure, stereochemistry, and activity against Kv1.3 are described.