Referenced in: none

Automatically associated channels: Nav1.5 , TRP , TRPM , TRPM4

Title: TRPM4 channels in the cardiovascular system.

Authors: Martin Kruse, Olaf Pongs

Journal, date & volume: Curr Opin Pharmacol, 2014 Apr , 15, 68-73

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24721656

Abstract
The non-selective Transient Receptor Potential Melastatin 4 (TRPM4) cation channel is abundantly expressed in cardiac cells, being involved in several aspects of cardiac rhythmicity, including cardiac conduction, pace making and action-potential repolarization. Dominantly inherited mutations in the TRPM4 gene are associated with the cardiac bundle-branch disorder progressive familial heart block type I (PFHBI) and isolated cardiac conduction disease (ICCD) giving rise to atrio-ventricular conduction block (AVB), right bundle branch block, bradycardia, and the Brugada syndrome. The mutant phenotypes closely resemble those associated with mutations in the SCN5A gene, encoding the voltage-gated Na(+) channel NaV1.5. These observations and the unexpected partnership with sulfonylurea-receptors (SURs) makes the TRPM4 channel a promising novel target for treatment of cardiac disorders.