PubMed 19100032

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Title: [Detection of gene mutations of SCN5A in 7 patients with Brugada syndrome]

Authors: Bin-bin Yuan, Qi-jun Shan, Bing Yang, Ming-long Chen, Jian-Gang Zou, Chun Chen, Dong-Jie Xu, Ke-Jiang Cao

Journal, date & volume: Zhonghua Xin Xue Guan Bing Za Zhi, 2008 May , 36, 404-7

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Brugada syndrome is linked to sodium channel mutations and could induce arrhythmias that even lead to sudden death. The purpose of this study was to detect if there was gene mutation of SCN5A in 7 patients with Brugada syndrome and explore the molecular genetic characteristics of this disease.Genomic DNA was extracted from peripheral blood of all 7 patients with Brugada syndrome and 41 pairs of PCR primers were designed to amplify all the 28 exons of SCN5A.There was no novel mutation in exons of Gene SCN5A in these patients with Brugada syndrome.Brugada syndrome might associated gene mutation or other mechanisms independent of SCN5A gene mutation.