Referenced in: none

Automatically associated channels: Kv11.1 , Nav1.2 , Nav1.5 , Nav1.7 , Nav1.8

Title: Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.

Authors: Michael E Kort, Irene Drizin, Robert J Gregg, Marc J C Scanio, Lei Shi, Michael F Gross, Robert N Atkinson, Matthew S Johnson, Gregory J Pacofsky, James B Thomas, William A Carroll, Michael J Krambis, Dong Liu, Char-Chang Shieh, XuFeng Zhang, Gricelda Hernandez, Joseph P Mikusa, Chengmin Zhong, Shailen Joshi, Prisca Honore, Rosemarie Roeloffs, Kennan C Marsh, Bernard P Murray, Jinrong Liu, Stephen Werness, Connie R Faltynek, Douglas S Krafte, Michael F Jarvis, Mark L Chapman, Brian E Marron

Journal, date & volume: J. Med. Chem., 2008 Feb 14 , 51, 407-16

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18176998

Abstract