PubMed 17420262

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Title: Brugada syndrome masquerading as febrile seizures.

Authors: Jonathan Robert Skinner, Seo-Kyung Chung, Carey-Anne Nel, Andrew Neil Shelling, Jackie Robyn Crawford, Neil McKenzie, Ralph Pinnock, John Kerswell French, Mark Ian Rees

Journal, date & volume: Pediatrics, 2007 May , 119, e1206-11

PubMed link:

Fever can precipitate ventricular tachycardia in adults with Brugada syndrome, but such a link has not been reported in children. A 21-month-old white girl presented repeatedly with decreased conscious level and seizures during fever. During a typical episode, rapid ventricular tachycardia was documented. The resting 12-lead electrocardiogram revealed a Brugada electrocardiogram signature. Resting electrocardiograms of the asymptomatic brother and mother were normal, but fever in the mother and pharmacologic stress with ajmaline in the brother revealed Brugada electrocardiogram features. Genetic testing revealed an SCN5A mutation in the affected family members.