Channelpedia

PubMed 8352767


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.2



Title: A computational model of the HBK2 potassium channel ion pore.

Authors: A Y Jin, D F Weaver

Journal, date & volume: Biochem. Biophys. Res. Commun., 1993 Aug 16 , 194, 1117-23

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8352767


Abstract
A computational model of the putative ion pore region of the HBK2 potassium channel was developed. Utilizing experimentally derived constraints, conformations corresponding to both the open and closed states of the ion pore were determined. Also, a conformational basis for the different sensitivites of the internal and external tetraethylammonium binding sites has been proposed. The model presented here suggests a role for other regions of the HBK2 protein in determining the ion pore conformation.