Referenced in: none

Automatically associated channels: Kv1.2 , Kv1.4

Title: Absence of effects of class III antiarrhythmic agents on cloned cardiac K channels.

Authors: T Yamagishi, K Ishii, N Taira

Journal, date & volume: Jpn. J. Pharmacol., 1993 Apr , 61, 371-3

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8320883

Abstract
We investigated the effects of class III antiarrhythmic agents, d-sotalol, E-4031 and MS-551, on the currents of two cloned K channels, Kv1.2 (IKv1.2) and Kv1.4(IKv1.4), by using the Xenopus oocyte expression system. Both IKv1.2 and IKv1.4 were sensitive to 4-aminopyridine and quinidine, but insensitive to tetraethylammonium, d-sotalol, E-4031 and MS-551. The results suggest that some types of structural proteins may be necessary for class III agents to inhibit the cardiac cloned K channels.